Key Research Projects & Publications

Ethics and Research Compliance

All research activities are conducted following institutional ethical guidelines and are approved by the Institutional Ethics Committee of Sree Balaji Dental College & Hospital. The centre adheres to national and international standards for responsible biomedical research.

The Human Genetics Research Centre has undertaken diverse research projects spanning molecular genetics, biomarker discovery, genetic counselling, microbial genomics, and translational dentistry, contributing significantly to understanding the genetic basis of oral and systemic diseases.

Government Funding Agency

S. No	Name of Funding Agency	File Number	Year	Principal Investigator	Amount	Status
1	DST-FIST (Funds for Science and Technology Infrastructure)	SR/FST/College-2017/23 (C)	2018 - 2023	Dr. S. Usha	₹45 Lakhs	Completed

RESEARCH PROJECTS

ONGOING PROJECTS

S. No	Project Title
1	Mitochondrial Dysfunction Analysis in Cardiovascular Disease
2	Mitochondrial Dysfunction Analysis in Periodontitis with Coronary Artery Disease
3	Mitochondrial Dysfunction Analysis in Hypertension Associated with Cardiovascular Disease
4	Genetic Variant Analysis of Dental Diseases in Association with Metabolic and Systemic Illnesses including Diabetes, Cardiovascular Diseases, and Hypertension
5	Molecular Investigation of Oral and Systemic Disease Risk Factors
6	Investigation of Enhanced External Counterpulsation (EECP)-treated Patients with Coronary Artery Disease
7	Pharmacogenomic Analysis of Systemic Diseases
8	Mutation Analysis in Rare Orofacial Malformations

COMPLETED PROJECTS

S. No	Project Title
Genetic Polymorphism and SNP Studies
9	Polymorphism of GSTP1 (rs1695) and its association with dental caries
10	Genetic variant analysis of ALOX12 (rs9904779) gene in dental caries
11	Computational analysis of non-synonymous SNPs in the human LCN2 gene
12	In-silico analysis of non-synonymous SNPs in the human WWOX gene
13	Characterization of missense SNPs in RUNX2 gene
14	In-silico prediction of deleterious SNPs in STAT3 gene
15	Prediction of deleterious non-synonymous SNPs in Cathelicidin gene
16	In-silico screening of SNPs in TUFT1 gene
17	Determination of deleterious SNPs in LYZC gene
18	Determination of deleterious SNPs in Lactoferrin gene
19	In-silico analysis of SNPs in DEFB1 gene
Molecular and Biomarker Studies
20	Genetic polymorphism and gene expression of β-Defensin-1 in periodontitis associated with Type 2 diabetes mellitus
21	Role of β-Defensin-1 against Porphyromonas gingivalis LPS-mediated inflammation in THP-1 cell line
22	Differential expression of Caveolin-3, ST2, and Growth Differentiation Factor-15 genes associated with acute myocardial infarction
23	Saliva as a biomarker tool for disease detection
24	Salivary secretory proteins – genetic polymorphism and disease association
25	Single nucleotide polymorphisms of salivary antimicrobial peptides in periodontitis
Herbal and Antimicrobial Research
26	Biosynthesis of Copper Oxide nanoparticles from Hibiscus rosa-sinensis and evaluation against Pseudomonas aeruginosa
27	Effects of Ginkgo biloba and Anacyclus pyrethrum extracts against Streptococcus species in dental caries and periodontitis
28	Combating antibiotic resistance in chronic periodontitis through plasmid dissemination in Enterococcus faecalis
29	In-silico targeting of red complex bacteria virulence factors with β-Defensin-1
30	Effect of Chitosan nanoparticles and herbal extracts in combating plasmid-mediated resistance in periodontitis
31	Designing universal primers for identification of erythromycin and tetracycline resistance genes in oral streptococci
Disease Association and Translational Genetics
32	Immune dysfunction linking periodontitis and diabetes management
33	DNA repair gene polymorphism in oral premalignant disorders with habitual risk factors
34	Human papillomavirus infection status and oral cancer incidence in South India
35	Genetic variations in signaling pathways in apical periodontitis
36	Genetic analysis in pain-associated deep caries
37	Role of genetics in dentistry
38	Role of neutrophils in periodontitis

HGRC RESEARCH OUTPUT (PUBLICATIONS, CITATIONS, H-INDEX)

S. No	Name	Source	H-Index	i10-Index	Total Citations
1	Dr. S. Usha	Google Scholar	10	11	421
1	Dr. S. Usha	Scopus	8	-	201
2	Dr. M. Sudhan	Google Scholar	1	-	2
2	Dr. M. Sudhan	Scopus	3	-	20

GLIMPSES OF THE DST-FIST REVIEW AND FACILITY EVALUATION

June 17, 2021: DST - FIST Review Meeting with DST Committee members

August 3, 2022: DST - FIST Review meeting with Committee members

COLLABORATIONS & PARTNER INSTITUTIONS

The Human Genetics Research Centre (HGRC) actively collaborates with national and international academic institutions, research laboratories, and healthcare organizations to advance interdisciplinary research in genomics, molecular biology, and translational medicine. These collaborations facilitate knowledge exchange, joint research projects, and capacity building in genetic and biomedical sciences.

INTERNATIONAL COLLABORATION

January 24, 2025: International collaboration project initiative meeting with Prof. Nik, Registrar Dr. S. Bhuminathan, BIHER, and the Dean from Chiang Mai University, Thailand, Cleft and craniofacial Centre team of SBMCH.

NATIONAL COLLABORATION

July 26, 2025: Dr Ginokurian's Cardiovascular Biology Lab, SASTRA University, Thanjavur.

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