1. Immunohistochemistry study currently working on 14 different antibodies
2. Study on HPV prevalence and its significance in the prognosis of pre cancer and cancer of oral cavity- (N-200). (completed- 30% of work)
3. Early epigenetic changes contributing to the aggressiveness of oral cancer as well as to predict malignant transformation potential of potentially malignant disorders of oral cavity. (N-200) (completed 50% of sample collection)
4. Identification of diagnostic and prognostic markers in Oral squamous cell carcinoma and oral potentially malignant disorders. Development of low cost and rapid diagnostic kits for Oral squamous cell carcinoma and oral potentially malignant disorders. The molecular techniques used here are, exome sequencing, transcriptome sequencing, PCR, IHC and ELISA.
5. Repurposing of various drugs as adjunctive to Chemotherapy and Radiotherapy in Oral Squamous cell carcinoma. The preliminary work is on Oral cancer and normal oral epithelial cell lines.
6. Identifying various protein markers which can be used as diagnostic markers in low cost settings like places of mass screening, primary health centres etc. The technique used are two dimensional gel electrophoresis, IHC and ELISA.
7. Identification of secretory markers in Oral cancer and potential markers using Raman Spectroscopy (work is in very early phase).
8. Identification of diagnostic and prognostic markers in Oral Cancer and Oral Potentially Malignant Disorder using Spatial transcriptomics study (Applied for funding).
9. LIP PRINT PATTERNS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA AND ORAL POTENTIALLY MALIGNANT DISORDERS
10. ANTIFUNGAL EFFICACY OF LACTOBACILLUS SPECIES AGAINST CANDIDA ISOLATED FROM ORAL SQUAMOUS CELL CARCINOMA PATIENTS – AN INVITRO STUDY
11. ECO-INSPIRED SYNTHESIS OF SELENIUM NANOPARTICLES USING ILLICIUM COCPAR PROJECT OUTLINE RECENT ON-GOING PROJECTS VERUM: UNVEILING ANTIOXIDANT, ANTIMICROBIAL,ANTI-CANCER,ANTI-INFLAMMATORY POTENTIALS.
12. The biogenic synthesis of copper nanoparticles using Cinnamomum tamala and its therapeutic action as anticancer, anti-inflammatory, antimicrobial, and antioxidant.
13. Cinnamomum verum mediated synthesis of copper nanoparticles and assessment of its anti- inflammatory, antioxidant, anticancer and antimicrobial potential.
| S. No | Ongoing Research Projects | Year of Commencement | Name of Staff / Student / Intern | Total Cost (INR) | Funding Agency |
| 1 | Oral Cancer Screening – Screening of patients and attendants reporting to OP | 2013 | Dr. Vidyarani Shyamsundar, Dr. S. Karthika Nagarajan | 25,000 | BIHER Funding |
| 2 | Re-purposing of Antihypertensive Drugs (Beta Blockers) and NSAIDs in OSCC – Preclinical studies | 2018 | Dr. Vidyarani Shyamsundar | 18,50,000 | DST-SERB |
| 3 | Important markers to assess prognosis of Oral Cancer and potentially malignant disorders | 2014 | Dr. Vidyarani Shyamsundar | 3,50,000 | BIHER Funding |
| 4 | Importance of EMT markers in Oral Cancer and potentially malignant disorders | 2015 | Dr. Vidyarani Shyamsundar | 1,00,000 | BIHER Funding |
| 5 | Single nucleotide polymorphism in OSCC and OPML | 2016 | Dr. Vidyarani Shyamsundar | 4,00,000 | BIHER Funding |
| 6 | Specific phytochemical as chemopreventive drug – Preliminary work | 2017 | Dr. Vidyarani Shyamsundar | 1,00,000 | BIHER Funding |
| 7 | Prevalence and virulence characterization of Candida in PMDs and OSCC | 2015 | Dr. Leena Sankari | 25,000 | BIHER Funding |
| 8 | Association of EBV in OSCC and potentially malignant disorders | 2016 | Dr. Leena Sankari, Dr. Kailash | 20,000 | BIHER Funding |
| 9 | Association of MMP-2 and MMP-9 in PMDs and OSCC using ELISA | 2016 | Dr. Vidyarani Shyamsundar, Dr. Sona | 70,000 | BIHER Funding |
| 10 | Assessment of HIV status among dental OP patients using ELISA | 2017 | Dr. Vidyarani Shyamsundar, Dr. Krishna Prasanth, Dr. Karthika Nagarajan | 60,000 | BIHER Funding |
| 11 | Phytochemical analysis of herbal extract for antioxidant & anti-inflammatory applications in PMDs | 2017 | Dr. S. Karthika Nagarajan | 45,000 | BIHER Funding |
| 12 | Expression of Anti-MRP8 in OSCC & OPMD | 2019 | Dr. Hariharan, Dr. Vidyarani Shyamsundar, Dr. KMK Masthan | 40,000 | BIHER Funding |
| 13 | Expression of Anti-Cystatin A in OSCC & OPMD | 2019 | Dr. Sangeethapriya P, Dr. Vidyarani Shyamsundar, Dr. KMK Masthan | 40,000 | BIHER Funding |
| 14 | Expression of Anti-Cystatin B in OSCC & OPMD | 2019 | Dr. Sudakshina Mukherjee, Dr. Vidyarani Shyamsundar, Dr. KMK Masthan | 40,000 | BIHER Funding |
| 15 | Expression of S-100A9 in OSCC & OPMD | 2019 | Dr. E. P. Sridevi Anjuga, Dr. Vidyarani Shyamsundar, Dr. KMK Masthan | 40,000 | BIHER Funding |
| 16 | Expression of S-100A11 in OSCC & OPMD | 2019 | Dr. Sherene A. M, Dr. Vidyarani Shyamsundar, Dr. KMK Masthan | 40,000 | BIHER Funding |
Sree Balaji Dental College & Hospital,
Velachery Main Road,
Narayanapuram, Pallikaranai,
Chennai - 600 100. Tamilnadu, India
sbdchcprincipaloffice@gmail.com
Phone: 044-22462179 / 22461883
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