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Research Focus Area

Cleft & Craniofacial Orthodontics Research | Clinical Trials & Public Health | SBDCH


Advancing evidence-based cleft care, translational research, and national data systems in India. Our Cleft & Craniofacial Orthodontics Research Unit focuses on clinical trials, public health innovation, and national registry development to improve patient outcomes and healthcare delivery.


1. Clinical Trials in Cleft Orthodontics


We conduct high-impact clinical trials in cleft orthodontics to optimize treatment protocols and improve long-term outcomes


Nasoalveolar Moulding (NAM) Research
  • Evidence-based evaluation of nasoalveolar moulding (NAM)
  • Digital and customized NAM innovations
  • Long-term outcomes in cleft lip and palate patients

Pre-Alveolar Bone Graft Orthodontics
  • Presurgical orthodontic optimization
  • Improving alveolar bone graft success rates
  • Enhancing dental arch stability

Orthodontic Outcomes in Cleft Patients
  • Longitudinal evaluation of occlusion, facial esthetics, and airway
  • Patient-reported outcomes and quality of life (OHRQoL)
  • Functional and esthetic outcome assessment

Multicentric Clinical Trials
  • Collaborative national and international research
  • Generation of high-quality, generalizable clinical evidence

2. Public Health & Health Services Research in Cleft Care


We address healthcare delivery, accessibility, and policy development in cleft care in India.


National Audits of Cleft Care
  • Benchmarking treatment outcomes
  • Identifying variations in cleft care delivery

Standardized Cleft Care Pathways
  • Development of evidence-based multidisciplinary protocols
  • Integration of orthodontics, surgery, and speech therapy

Health Economic Evaluation
  • Cost-effectiveness of cleft treatments in India
  • Supporting affordable and sustainable cleft care models

Access, Equity & Community Outreach
  • Addressing barriers to cleft treatment
  • Strengthening rural and underserved healthcare access

3. Translational Research in Cleft Orthodontics


We bridge the gap between clinical research and real-world patient care.


Evidence-to-Practice Translation
  • Implementation of clinical trial outcomes into routine care
  • Adoption of digital orthodontics and AI-based treatment planning

Pre-Alveolar Bone Graft Orthodontics
  • Presurgical orthodontic optimization
  • Improving alveolar bone graft success rates
  • Enhancing dental arch stability

Clinical Protocol Development
  • Standard operating procedures (SOPs) in cleft care
  • Personalized, precision-based orthodontic treatment

Guidelines & Policy Development
  • Contribution to national cleft care guidelines in India
  • Alignment with global best practices

4. National Cleft Data Registry – India


We are working toward establishing a comprehensive Indian cleft patient registry to support large-scale research and policy planning.


Cleft Lip and Palate Registry
  • Centralized database for clinical and demographic data
  • Longitudinal outcome tracking

Big Data & AI in Cleft Research
  • Multicentric data integration
  • Predictive analytics and outcome modeling

Quality Improvement & Benchmarking
  • Continuous monitoring of treatment outcomes
  • Enhancing transparency and standardization

Major Funded Research Projects


# Project Title Funding Agency Grant Study Design Key Objectives Impact
1 NAMUC Study
Nasoalveolar Moulding in Unilateral Cleft
DBT Wellcome Trust India Alliance ₹4.67 Cr Multicentric Randomized Clinical Trial Evaluate effectiveness of NAM in unilateral cleft lip and palate Improve early outcomes and reduce treatment burden
2 PABO Study
Pre-Alveolar Bone Graft Orthodontics
SERB ₹43.9 L Multicentre Randomized Clinical Trial Assess presurgical orthodontic effectiveness Improve graft success and treatment planning
3 CCIS Study
Cleft Care India Study
SPARC / Stichting Sumbing Bibir ₹1.1 Cr Multicentre Audit & Economic Study Evaluate outcomes and cost-effectiveness Support policy and standardized care pathways
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