Dentistry @ SBDCH | Best Pvt College in Chennai

Projects

RESEARCH PROJECTS

S. NO	NAME OF FUNDING AGENCY	FILE NUMBER	NAME OF THE PRINCIPAL INVESTIGATOR	AMOUNT (RS IN LAKHS)	STATUS (ONGOING/ COMPLETED)
1	DST-FIST (Funds for science and technology infrastructure)	SR/FST/College-2017/23 (C)	Dr. Usha Subbiah	45	Completed

ONGOING PROJECTS

Genetic variant analysis of Dental diseases in association with metabolic and systemic illness including Diabetes, Cardiovascular diseases and Hypertension.
Molecular investigation of oral and systemic disease risk.
Mutation analysis in rare oro-facial malformations.

COMPLETED PROJECTS

Polymorphism of GSTP1 (rs1695) and its Potential Association with Dental Caries
Investigation of genetic variants of AloX12 (rs9904779) gene in dental caries
Computational analysis of non-synonymous SNPs in the human LCN2 gene
In Silico Analysis of Non-Synonymous Snps in the Human WWOX Gene
Characterization of missense nonsynonymous single-nucleotide polymorphism of runt-related transcription factor-2 gene
In silico Prediction of Deleterious Non-Syonymous SNPs in STAT3
Biosynthesis of Copper Oxide Nano Particles from Hibiscus Rosa Sinensis and its Efficacy against Pseudomonas Aeruginosa
Genetic Polymorphism and Gene Expression of β-Defensin-1 in Periodontitis Associated With Type 2 Diabetes Mellitus
Role of β-Defensin 1 Against Porphyromonas gingivalis Lipopolysaccharide-Mediated Inflammation in the THP-1 Cell Line
Effects of Ginkgo biloba and Anacyclus pyrethrum against Streptococcus species isolated from dental caries and periodontitis
Combatting antibiotic resistance in chronic periodontitis by dissemination of plasmid in enterococcus faecalis
Prediction of Deleterious Non-Synonymous Single Nucleotide Polymorphism of Cathelicidin
In silico screening of non-synonymous SNPs in human TUFT1 gene
Molecular Docking and Dynamics Simulation of Orthosiphon stamineus against SGLT1 and SGLT2
Differential expression of caveolin-3 suppression of tumorigenicity 2 and growth differentiation factor-15 genes and its association with acute myocardial infarction
Determination of deleterious single nucleotide polymorphisms of human LYZ C gene
Determination of deleterious single nucleotide polymorphisms of human lactoferrin gene
Insilico targetting of red complex bacteria virulence factors of periodontitis with b-defensin 1
Association of β-defensin 1 gene polymorphism and dental caries susceptibility
Saliva As A Biomarker Tool
Immune Dysfunction Linking Periodontitis And Diabetes Management
DNA Repair Gene Polymorphism In Oral Premalignant Disorders Associated With Habitual Risk Factors.
In silico analysis of non-synonymous single nucleotide polymorphisms of human DEFB1 gene
Single Nucleotide Polymorphisms of Salivary Antimicrobial Peptides in Periodontitis
Effect of Chitosan, Chitosan Nanoparticle, Anacyclus pyrethrum and Cyperus rotundus in combating Plasmid Mediated Resistance in Periodontitis
Salivary Secretory Proteins-Unveiling Genetic Polymorphism and Diseases
Single Nucleotide Polymorphism of Salivary Antimicrobial Peptides in Periodontitis
Human Papilloma Virus Infection Status and Oral Cancer incidence in South India
Signaling Pathway Genetic Variations in Apcial Periodontitis
Genetic Analysis In Pain Associated Deep Caries
Designing Universal Primer For The Identification Of Erythromycin And Tetracycline Resistance Genes In Oral Streptococci
Role of Genetics in Dentistry
Neutrophils in periodontitis
Enhanced Oxidistability Of Lipoproteins In Radiation Treated Oral Cancer Cases, Interfered By Antioxidant Selenium

RESEARCH OUTPUT AND IMPACT ON SOCIETY

Genetic Investigation of patients with periodontitis and CVD

This study elucidates the molecular and genetic interplay between cardiovascular diseases (CVD) and periodontitis through functional assays, gene expression profiling, and protein-level investigations. By identifying key polymorphic sites, differentially expressed genes, and altered protein pathways, the research contributes to a deeper understanding of shared inflammatory mechanisms and systemic effects linking oral and cardiovascular health.

The findings have significant translational potential. They pave the way for the development of early diagnostic markers for both CVD and periodontal disease, addressing the current lack of predictive tests. Integrating genetic risk profiling into clinical practice can revolutionize disease management through personalized preventive strategies.

Overall, this study enhances the scientific foundation for integrated oral-systemic healthcare, ultimately improving patient outcomes and reducing the burden of chronic inflammatory diseases on society.

Genetic Investigation of patients with FACIAL CLEFT

The study on Facial Cleft and Supernumerary Tooth Formation contributes significantly to the understanding of craniofacial developmental anomalies and their potential genetic underpinnings. By investigating associations between dental anomalies and specific gene polymorphisms, this research aids in identifying genetic markers linked to syndromic conditions like facial cleft and abnormal tooth number. These findings expand the current knowledge base and pave the way for the development of early diagnostic tools.

From a societal standpoint, this research holds immense potential for early detection and personalized intervention. It promotes the possibility of predictive genetic testing, which can forecast susceptibility to congenital dental anomalies and associated periodontal conditions even before clinical symptoms arise. Additionally, incorporating genetic counseling into dental care enables the creation of detailed family pedigrees, helping to establish inheritance patterns. This can lead to targeted monitoring and early treatment of at-risk individuals, significantly reducing long-term oral health complications and improving quality of life.

Ultimately, the study supports the integration of genomic medicine into routine dental practice, fostering a more preventive, personalized, and effective approach to managing craniofacial and periodontal diseases.