Research Projects

Ongoing Projects

The Department of Oral and Maxillofacial Surgery is equipped with specialty text books and journals related to the following subjects namely Dental Materials, Oral and Maxillofacial Surgery.

• Genetic variant analysis and gene expression in periodontitis and type 2 diabetes mellitus
• Molecular investigation of oral premalignant disorders and oral cancer
• Salivary peptides polymorphism in periodontitis associated with type 2 diabetes mellitus
• Analysis of genetic polymorphism in dental caries susceptibility
• Gene expression analysis in oral diseases.
• Qualitative and quantitative assessment of HPV status to identify high risk individuals for potential to develop oral and oro-pharyngeal squamous cell carcinoma
• In silico single nucleotide polymorphism analysis

Completed Projects

• Gene polymorphism in dental caries
• Prediction of Molecular Docking and Dynamics Simulation of Orthosiphon stamineus against SGLT1 and SGLT2
• Insilico SNP analysis of peptides
• Effect of chitosan and chitosan nanoparticle, Anacyclus pyrethrum and Cyperus rotundus in combating plasmid mediated resistance in periodontitis
• Molecular identification of 16s rRNA of chronic periodontal pathogens
• Effect of Cyperus rotundus in combating plasmid mediated resistance in periodontitis
• Dissemination of Enterococcus faecalis plasmid in combatting antibiotic resistance in chronic periodontitis
• Analysis of 16s rRNA of Ralstonia pickettii and Bacillus safensis of chronic periodontitis
• Plasmid mediated antibiotic resistance in E. coli isolated from chronic periodontitis
• Bacterial prevalence in edentulous patients
• 16s rRNA gene-based metagenomic analysis identifies a novel bacterial co-prevalence pattern in dental caries.
• A novel mutation in ROGDI gene is associated with kohl-shutter tonz syndrome



Research Output and Impact on society




Genetic Investigation of patients with periodontitis and endodontic infections.



• Some syndromes are associated with gingival enlargement, gingival bleeding, gingival fibromatosis, periodontitis, alveolar bone loss, and tooth loss. Hence investigating the association between periodontitis and polymorphic site on gene expands the knowledge for the future development in diagnostic markers for assessment of risk for periodontal and caries disease.
• A predictive test for dental caries or for periodontal disease does not currently exist. Since these are both complex diseases with multiple genetic and environmental risk factors, quantifying risk will require multifaceted assessment including genetic variant analysis in diseased population.
• Genetic information about an individual’s risk profile may change how disease is managed. Identifying the genetic polymorphism, mutations in the risk allele and their role in periodontal disease and caries will provide the likelihood of disease initiation before it occur.
• Genetic counseling will help to draw a pedigree chart which can help to establish the mode of inheritance in family of patient. Once the mode of inheritance is established, we can predict the susceptible member for the disease and thus treatment can be started.

Genetic Investigation in oral cancer

• Identification of gene expression in oral cancer insight into how to therapeutically navigate and target with precision the molecular networks and genetic mutations that drive neoplastic development and progression.
• If genetic risks could be identified prior to the occurrence of premalignant disorders and caries lesions, minimal treatment cost could be used as well as alleviate the patient's pain and suffering from oral disorders.
• Besides this, the environmental and behavioural factors which influence the risk of oral cancer and the community should be made aware of the importance of good alternative oral hygiene behaviours and daily habits.

Bacterial Genetic element Screening of patients with oral diseases

• Screening for plasmid in oral pathogens towards susceptibility which helps in understanding the chain of transmission of oral bacterial resistance and facilitate the development of the alternative antimicrobial administration besides the administration of available higher generation of antibiotics to patients in the dental practice
• This allows a family dentist to offer effective preventive and alternative treatment strategies for oral diseases..